(E-H) Abundance of CD49b+ (E), NKp46+ (F), Granzyme B+ (G) and different development status (H) tumor infiltrating NK cells. (I) Representing immunohistochemistry images of SLC7A11, GPX4, MDA and ...

Acute graft-versus-host disease (aGVHD) is a common life-threatening complication after allogenic hematopoietic cell transplantation. Administration of immunosuppressive regimes is the main therapy ...

Analysis of bulk RNAseq data of naïve WT and Cd47 −/− spleen cells depleted for proerythroblasts through mature erythrocytes using the antibody Ter-119 (Kina et al., 2000) and for cells bearing CD4, ...

The loss of CD49b induced a defective migration of effector cells into the BM. Then, to examine a role of CD49b in the maintenance of memory CD4 T cells, we inhibited the integrin during memory phase ...

Objective Recently, a new subtype of granzyme B (GrB)-producing Breg cells has been identified, which was proven to be involved in autoimmune disease. Our recent report demonstrated that GrB-producing ...

We describe a new role for Mg in suppressing arthritis, in expanding Foxp3+ T reg cells and in the production of IL-10, and show that these effects are mediated by the intestinal microbiome. Our ...

Meanwhile, the intracellular domain of CD49b was not readily labeled as its extracellular domain by corresponding antibodies, indicating the right-side-out orientation of the PLT-PFCs. Next, we tested ...

CD49b also promoted relocalization of T cells at a greater distance from tumor cells. Thus, our results demonstrate that expression of these integrins affects T-cell trafficking and localization in ...

Tumors were dissected and sent to HistoTox for embedding, slicing and staining for H&E, NKp46, CD3, CD49b, AC3, CD31, B220, Ly6G, Sca-1, and PSR. Results: Mice treated with repeat doses of AVM0703 did ...

Co‐expression of CD49b and LAG‐3, without Foxp3, on CD4 T cells is consistent with the induction of Tr1‐type Treg cells 14. Assessment of other markers expressed by Tr1 cells revealed that the induced ...

New immunotherapy technique holds promise for curing food allergies Date: October 26, 2016 Source: University of Saskatchewan Summary: A new immunotherapy technique has been developed that nearly ...