Aim: To investigate the mechanism(s) by which the intestinal commensal microbe Lactobacillus acidophilus can affect host immunity, we studied the role of a component of the cell wall, lipoteichoic ...

Elevated levels of IL-6 have been detected in the blood and in the cultures of colonic mucosal specimens from CD patients. [82, 83] In a colitis mouse model generated by transfer of CD45RB high ...

The therapeutic effects were further studied in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis and CD4 + CD45RB hi T cell transfer colitis. Results Intracolonic administration of the ...

FOXP3-expressing regulatory T (T reg) cells play a pivotal role in maintaining immune homeostasis and tolerance, with their activation being crucial for preventing various inflammatory responses.

We examined differentiation of T-helper cells, frequency of innate immune cells, and cytokine production by dendritic cells (DCs) in the colon from DSS-treated mice after PD-L1-Fc administration. In ...

Immune Tolerance Laboratory, Medicine, University of New South Wales, Sydney, NSW, Australia Antigen specific T regulatory cells (T reg) are often CD4 + CD25 + FoxP3 + T cells, with a phenotype ...

1 GAZI UNIVERSITY SCHOOL OF MEDICINE, IMMUNOLOGY, Türkiye Introduction: Age-related phenotypic alterations have been indentified in lymphocytes. However, the effect of aging on lymphocyte surface ...

After antigenic activation, quiescent naive CD4 + T cells alter their metabolism to proliferate. This metabolic shift increases production of nucleotides, amino acids, fatty acids, and sterols. Here, ...

Unsensitized mice did not receive splenic CD4 + CD45RB low CD25 − T cells and were fed with either gluten‐free diet or gluten‐containing diet. CRAMP (the mature form; 088328; GL biochem, Shanghai, ...

This molecule has been previously been shown to activate CD4 + CD45RB low T-cells to produce IL-10. We are currently investigating the anti-inflammatory properties of this molecule for the treatment ...

Foxp3 + regulatory T cells are primarily generated in the thymus (tT reg) or extrathymically at peripheral tissues (pT reg). They may also be induced in vitro (iT reg) in the presence of transforming ...

Colorectal cancer (CRC) is one of the leading causes of death in the western society, being ranked third most lethal neoplasia in the United States in both men and women. 1 In 2014, the American ...