Immunotherapy has revolutionized cancer treatment by mobilizing the immune system to attack tumor cells. Major advances, such as immune checkpoint inhibitors (notably against the PD-1 protein), have ...

Microglia are a specialized type of immune cell that accounts for about 10% of all cells within the brain and spinal cord. They function by eliminating infectious microbes, dead cells, and aggregated ...

Binding in these CD11b-rich organs was significantly reduced by coadministering the dose with nonradiolabeled anti-CD11b-IgG and anti-EphA2-CD11b-BsAb, with a concurrent increase in tumor uptake ...

Baseline CD18 neutrophil expression in Patient 3 in 5.8% of cells with CD11a or CD11b neutrophil expression of less than 2% most likely indicates abnormal or unstable protein.

Semaglutide, a glucagon-like peptide-1 receptor agonist, has been shown to reduce the risk of adverse cardiovascular events in patients with diabetes. Whether semaglutide can reduce cardiovascular ...

Yifan Wu et al. Toll-like receptor 4 and CD11b expressed on microglia coordinate eradication of Candida albicans cerebral mycosis. Cell Reports, 2023 DOI: 10.1016/j.celrep.2023.113240; ...

Asthma is a chronic, complex disease associated with heterogeneity in molecular pathways. Airway inflammation with different cell activation (e.g., eosinophils) and with hypersecretion of many ...

We found that CD11b and CD18 expression as well as the CD45 + CD11b + CD18 + myeloid cells were highly increased in the aorta of angiotensin II-infused mice. Ablation or pharmacological inhibition of ...

Background: GB1275 is a first-in-class, oral CD11b modulator that reduced myeloid-derived suppressor cells (MDSCs) and tumor associated macrophages (TAMs), repolarized M2 immunosuppressive TAMs to an ...