Rapt Therapeutics has conducted its second round of layoffs in just under a year, continuing a period of upheaval following ...

When the A and E sites are empty for a long time, a complex called CCR4-NOT degrades the message, and, as a result, less protein is made. "In yeast, the codon at the A site plays a major role in ...

RAPT Therapeutics to advance CCR4 compounds for inflammatory disease and expects to identify a new candidate in 1H 2025. RAPT Therapeutics laid off 47 people in July, or approximately 40% of the ...

Methods: CCR4 KO mice (spCas9 mice were injected with AAV8-CCR4-sgRNA into biolateral inguinal adipose tissue) were generated on a C57BL/6 background. Stromal vascular cells were isolated and ...

Last accessed: October 2024. 4 Ferenczi K, et al. Increased CCR4 expression in cutaneous T cell lymphoma. J Invest Dermatol. 2002;119:1405-10. 5 Yoshie O, et al. Frequent Expression of CCR4 in Adult T ...

We are pleased that one of the outcomes of our international collaborative research, the CCR4 CAR-T cell therapy, has led to a licensing arrangement for the development of potential new treatments by ...

We are pleased that one of the outcomes of our international collaborative research, the CCR4 CAR-T cell therapy, has led to a licensing arrangement for the development of potential new treatments ...

On the verge of top-line data from its phase IIb trial with oral small-molecule CC chemokine receptor 4 (CCR4) antagonist zelnecirnon in atopic dermatitis (AD), due around the middle of this year, ...

While CCR7 is known to promote thymocyte medullary entry and negative selection, our previous studies implicate CCR4 in these processes, raising the question of whether CCR4 and CCR7 play distinct or ...

CCL3, CCR4, cytokines, tight junction protein ZO-1, apoptosis-related genes and ERK1/2-NF-κB signaling pathway were detected by ELISA, Q-PCR, Western blotting and immunofluorescence. Conclusions: Our ...