Researchers have found in a new study that CCR2 shows strong potential as a biomarker for diseased aortic tissue in abdominal ...

Recent advances in cancer research have underscored the critical role of myeloid cells in shaping tumor microenvironments ...

ChemoCentryx, now part of Amgen, was developing a CCR2 inhibitor with Vifor Fresenius ... traditional binding inhibitors is MCP-1 couldn't dock. It actually led to a rebound effect where MCP ...

Objective Hepatocellular carcinoma (HCC) is an aggressive malignancy with limited effective treatment options. An alternative strategy is to target cells, such as tumour-infiltrating macrophages, in ...

The girls, however, didn't have the PAP autoantibodies. Instead, they had no CCR2 -- a newly identified genetic mutation. Perhaps its lack was connected to their pulmonary conditions, Neehus thought.

Although excessive immune responses by Th17 cells, a helper T cell subset, are implicated in the pathogenesis ... We generated C-C motif chemokine receptor 2 (CCR2) knockout (KO) and CCR6 KO mice in ...

unlike other chemokine ligands of CCR2, CCL16 is a negative regulator in liver diseases. It may limit the progression of liver fibrosis/cirrhosis by inhibiting the activation of HSCs. In addition, ...

Despite the scientists of the current study focusing on the role of CCR2 only in monocyte-derived cells, it is also expressed in other types of cells such as natural killer cells and T-cells.

Signaling within the CCL2/CCR2 axis shows underappreciated effects on myeloid cell survival and function polarization. Apart from myeloid cells, T cells are also known to express CCR2. Nevertheless, ...

To explore this clinical need, researchers identified chemokine receptor type 2 (CCR2) as a potential, novel biomarker for AAA evaluation. They developed the novel PET tracer, 64Cu-DOTA-ECL1i ...

Thus, CCR2+ cells represent a potential therapeutic target to improve ... Differences between groups were compared using paired parametric or unpaired nonparametric 2-tailed t tests. A P value of less ...