CCND1 and CCND2 bind either CDK4 or CDK6, the molecular targets of palbociclib, whereas CDK2 and CCNE1 form a related CDK kinase that promotes the G1/S transition. Similarly, cells with sgRNAs ...

CCND1 and CCND2 bind either CDK4 or CDK6, the molecular targets of palbociclib, whereas CDK2 and CCNE1 form a related CDK kinase that promotes the G1/S transition. Similarly, cells with sgRNAs ...

The molecular mechanisms underlying CHAF1A-mediated upregulation of c-MYC and CCND1 were elucidated. Aberrant Wnt signaling pathway plays a crucial role during the development of GC tumors [32,33].

We previously have ran code using Seurat pipeline before successfully. However, now using a similar pipeline, we consistently run into a problem when we use the RunPCA function and give it a set of ...

Evaluation of small extracellular vesicles as biomarkers of efficacy with anti-PD-1 mAb therapy in patients with recurrent/metastatic HNSCC. Abemaciclib in recurrent/metastatic head and neck squamous ...

Based on previous research into the role of proteins in cancer cells, the researchers suspect that these mutations primarily affect a protein called CCND1.

To characterize the molecular heterogeneity among the four genomic subtypes of cutaneous melanomas, the co-occurrence of CCND1 amplification with major driver mutations (BRAF V600, NRAS, NF1, and KIT) ...

In the remaining ESR1 wild-type patients, TP53 and PIK3CA mutations were each reported in 33% of patients, but CCND1 amplifications were in 2% and FGFR1 amplifications in 6%. Patients with ESR1 ...

FGF19 Enhances the Expression of CCND1 via FGF19–FGFR4–ERK1/2 Axis in LUSC. A number of growth factors are known to regulate CCND1 protein production (29, 30), and our analysis of TCGA database also ...

Located on chromosome 11q13.2, the CCND1 gene encodes Cyclin D1, a CDK-regulating protein that plays a critical role in cell cycle progression. Amplification of CCND1 is seen in about 10% of all ...