STAT3 and TET2 mutations are common, with unique subtypes defined by CCL22 mutations. Though indolent, treatment is only initiated in symptomatic cases. T-Prolymphocytic Leukemia (T-PLL) T-PLL is a ...

CCL22 controls immunity by promoting regulatory T cell communication with dendritic cells in lymph nodes. Journal of Experimental Medicine, 2019, 216:1170-1181. (JIF 10.8) Anz D, Rapp M, Eiber S, ...

The authors included a thoughtful discussion about hypothetical mechanisms explaining these contrasting results, including putative differences in the role played by the CCL17/CCL22-CCR4 axis along ...

School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, ...

Results: Here, we show that local LN removal greatly impairs cold-induced beiging, and this impairment can be restored by injecting M2 macrophages or macrophage-derived chemokine C-C motif ligand 22 ...

The origins of cancer vaccines date back to the 1800s. Since then, there have been significant efforts to generate vaccines against solid and hematologic malignancies using a variety of platforms. To ...

"We used this method to isolate aptamers that adhere to a certain immune protein called CCL22," says Mayer, who is also a member of the Transdisciplinary Research Areas "Matter" and "Life & Health ...

The team combined two components that help that goal into one drug: CCL22, which chemically attracts T-regs to a site, and IL-2, which amplifies them. These were then loaded into a microneedle ...

Bezisterim, an anti-inflammatory and insulin-sensitizer that permeates the blood brain barrier, could represent a novel oral treatment targeting an underlying cause of long COVID symptoms CARSON CITY, ...

Project FF-2014-01: Molecular mechanisms controlling DC migration in CNS autoimmunity (Judith Alferink, Martin Bähler, project time: 07/2014 - 06/2016) Alferink J, Specht S, Arends H, Schumak B, ...

Chemokines belong to a family of proteins called the cytokines and are involved in initiating and guiding the recruitment and migration of immune cells to sites of infection or damage. Chemokines ...