Treeline Biosciences Inc. has divulged proteolysis targeting chimeras (PROTACs) comprising cereblon (CRBN) ligands coupled to a Bcl-2-like protein 1 (Bcl-xl; Bcl-X; BCL2L1) targeting moiety via a ...

While UBX1325 was noninferior to Eylea at “most” time points through 36 weeks, according to the newly unveiled complete results, further development of the BCL-xL inhibitor could “benefit ...

(14) we used, for the first time, an isogenic cell line strategy (24) to evaluate the antiapoptotic genes bcl-2 and bcl-xL from human origin, bcl-2 and bcl-xL from CHO origin, mcl-1, and the apoptosis ...

The topline results come from the California company’s phase 2b study, dubbed Aspire, which is evaluating intravitreal UBX1325, a small molecule designed to inhibit BCL-xL. The double-masked ...

Microsoft has introduced the JPEG XL Image Extension add-on to allow Windows to support the JPEG-XL format. This add-on allows Windows users to view and save files using the .jxl file format.

Zhou and his collaborators developed a drug candidate that works by degrading two proteins, BCL-xl and BCL-2, that help senescent cells avoid death and promote MASLD progression. Without these ...

It took years to develop a compound that could selectively bind to BCL-2 without affecting related proteins like BCL-XL. The breakthrough came with venetoclax, which demonstrated efficacy as well as a ...

High expression of anti-apoptotic members such as BCL-XL commonly found in human cancer contributes to neoplastic cell expansion and interferes with the therapeutic action of many chemotherapeutic ...

Here, we show that tumor cell-derived GM-CSF triggers the expression of the anti-apoptotic Bcl-xL protein and enhances neutrophil survival through JAK/STAT signaling. Targeting Bcl-xL activity with a ...

Treeline Biosciences Inc. has described proteolysis targeting chimeras (PROTACs) comprising cereblon (CRBN) ligands coupled to a Bcl-2-like protein 1 (Bcl-xL; Bcl-X; BCL2L1) targeting moiety via ...