Patients with stages I to III breast cancer who were seen at a single cancer center between 2010 and 2012, and who agreed to participate in research DNA banking, were included (N = 488). Personal and ...

Ovarian cancer is the 6th most common cancer in females in the UK, accounting for 4% of all new cancer cases in females (2017-2019). In females and males combined, ovarian cancer is the 16th most ...

FANCJ, also known as BACH1 or BRIP1, was identified as a direct BRCA1-BRCT interacting protein and functions in DNA repair and checkpoint control. Bi-allelic inheritance of mutations in FANCJ ...

Twin sisters Christa Slatnik and Cindy Sanchez consider themselves ‘previvors’ after being diagnosed with a rare genetic mutation and having their ovaries removed earlier this month.

Reviewed By Eleonora Teplinsky, MD, Head of Breast Medical Oncology at Valley Health System in Paramus, New Jersey, Clinical Assistant Professor at Icahn School of Medicine at Mount Sinai in New ...

Introduction: BRIP1 (BRCA1-interacting protein 1) is one of the major interacting partners of BRCA1, which plays an important role in repair by homologous recombination (HR). This gene is mutated in ...

A recent survey of members of the Society of Gynecologic Oncology found that although recommendations and practices regarding RRSO for high-penetrance genes were consistent, there was significant ...

Those with family history might be at risk since a few genetic mutations are associated with ovarian cancer like, BRCA 1 and 2, Lynch syndrome, BRIP1, RAD51C, RAD51D. Some factors that may reduce ...