ABSTRACT: Background: Neurodevelopmental abnormalities in experimental fetal alcohol spectrum disorder (FASD) are associated with impaired signaling through complex pathways that mediate neuronal ...

Conclusions Epigenetic suppression of appropriate Wnt negative feedback loops is selectively advantageous in LD tumours and differential AXIN2 expression in LD/LI lesions can be exploited as a ...

mRNA analysis revealed that Wnt target genes AXIN2 and LEF1 can be significantly activated in E13.5 ECs when treated with Wnt3a or CHIR99021, while no significant activation was observed in adults ...

We share a case of a 40-year-old African American woman with a history of Asherman syndrome and asthma who was identified with a rare AXIN2 mutation through her hypodontia and detailed family history.

Macrophage lineages were examined in aortic and mitral valves of Axin2 KO (knockout) mice that exhibit myxomatous features. Infiltrating CCR2+ monocytes and expansion of CD206-expressing macrophages ...

CY-101 is a synthetic peptide with a dual mode of action that both inhibits the oncogenic Wnt/β-catenin pathway by activating Axin2 and has a pore-forming membranolytic effect on cancer cells that ...

The study, "RvE1 Promotes Axin2+Cell Regeneration and Reduces Bacterial Invasion," which appeared in The Journal of Dental Research, demonstrates regenerative properties of resolvins, specifically ...

Suppressing glycolysis in ASD mice partially rescued synaptic and social phenotype. Axin2, a key inhibitory molecule in Wnt signaling, interacts with the glycolytic enzyme enolase 1 (ENO1) in ASD ...

Using this method, they identified two key regulators, Axin2 and p53, which are involved in driving cell-cell competitive interaction. Specifically, Axin2-mutant stem cells were eliminated and even ...