The molecular complexity of mammalian proteomes demands new methods for mapping the organization of multiprotein complexes. Here, we combine mouse genetics and proteomics to characterize synapse ...

In their quest for answers, researchers pinpointed a specific protein, AP2A1 (Adaptor Protein Complex 2, Alpha 1 Subunit), which seems crucial to this cellular phenomenon. Found predominantly in ...

Scientists have discovered that AP2A1 controls cellular aging, making it a promising target for anti-aging therapies. Suppressing AP2A1 reverses aging in cells, while increasing it accelerates ...

Their work, published in the journal Cellular Signaling, reveals the key role of a protein, AP2A1, in the senescence process. This discovery paves the way for treatments that could reverse the effects ...

This protein, called AP2A1, could be the key to future treatments that will turn back the body's biological clock and undo the damage caused by old age. As our bodies get older, we build up a ...

“There are no sufficient data to supporting a potential therapeutic effect of interventions targeting AP2A1,” said Dr Lazaros Foukas (UCL Biosciences) on the reported therapeutic properties of ...

Researchers discovered that a protein called AP2A1 acts as a master switch controlling whether cells behave young or old When scientists reduced AP2A1 levels in aged cells, they showed signs of ...

This is the conclusion of researchers from the University of Osaka, who experimented with the expression of the protein "AP2A1" in cells of different ages. "The results were very intriguing," ...