Tetrahydroquinoline-based AMD070 is a potent and specific X4 HIV-1 inhibitor with high oral bioavailability; T22, an 18-mer anti-X4 HIV peptide, was designed from self-defense peptides isolated ...

ABSTRACT: The two known receptors, CXCR4 and CXCR7, for the chemokine stromal cell-derived factor-1 (SDF1) play a role in the development and metastasis of multiple cancers, including melanoma. CXCR4 ...

† Princess Margaret Cancer Centre and Techna Institute, University Health Network, Toronto, Ontario M5G1L7, Canada ‡ § ‡ Department of Medical Biophysics and § Institute of Biomaterials and Biomedical ...

The images at each time point were then measured using an area analysis via a wound healing tool in ImageJ. The CXCR4 inhibitor AMD070 hydrochloride (Sigma-Aldrich, St. Louis, MO, USA) and the CXCR7 ...

Only three small-molecule drugs targeting chemokine receptors have been approved: maraviroc, which targets CCR5, and AMD3100 and AMD070, which target CXCR4. Here, by resolving the high-resolution ...

To achieve these multimodal activities, we have covalently attached the CXCR4 antagonist, AMD070, to thiol-terminated polyethylene glycol (PEG) to synthesize AMD-PEG which was then conjugated with ...

Cancer immunotherapy has been established as standard of care in different tumor entities. After the first reports on synergistic effects with radiotherapy and the induction of abscopal effects—tumor ...