Rupitasertib is a selective oral inhibitor of S6K and AKT1/AKT3 designed to efficiently block the PI3K/AKT/mTOR (PAM) pathway while controlling the compensatory AKT feedback loop. In a Phase 1 trial ...

S6K, ribosomal S6 kinase; rpS6, ribosomal protein S6. Many studies have found that the PI3K/AKT/mTOR pathway is associated with cell proliferation, apoptosis, autophagy, and drug resistance of ESCC.

Specifically, the ERK, the AKT, and the S6K feedback loops attenuate signaling via growth factor receptors and other kinase receptors to regulate cell growth. Irregularity in any of these supervised ...

At early developmental stages, physiologically high PI3K-Akt-mTORC1 signaling suppresses expression of Krox20 (Egr2), the master regulator of PNS myelination. This effect is mediated by S6K and ...

Furthermore, integrated analysis of the hepatic Akt/mTORC1/S6K signaling axis allowed the delineation of the substrate specificity of several close-related kinases within the insulin signaling pathway ...

Osteoclasts are giant bone cells formed by fusion from monocytes and uniquely capable of a complete destruction of mineralized tissues. Previously, we have demonstrated that in energy-rich environment ...

Researchers homed in on a specific segment of this signalling pathway by analysing key proteins along it, called AKT, S6K and GSK3β, to see if their activation spurred cancer into action. Thirty eight ...

Thus, hypoxia induces sustained phosphorylation of Akt-Ser473, peaking at approximately 3 to 6 hours ... mTORC1 signaling is repressed as seen by complete dephosphorylation of S6K-Thr389. Blunting of ...

Bar graphics reflect the average ± SD of three independent experiments. (B) The phosphorylation levels of several components downstream of PI3K (Akt, S6K, FKHRL, GSK, and 4EBP1) were analyzed in ...