In contrast, the levels of their non-phosphorylated counterparts (PI3K, AKT, and MDM2) showed negligible changes. The reduced p-MDM2 was unable to exert its inhibitory function on P53, leading to ...

MYCN and MDM2 inhibition has gained attention not only in neuroblastoma but also in a spectrum of other cancer types ... AKT, protein kinase B; AURKA, aurora kinase A; FBXW7, F-Box and WD ...

Compared with the control group, RNA-seq, and KEGG analysis suggested that AKT/MDM2/P53 signaling was inhibited after knockdown of CCT6A in MDA-MB-231. Furthermore, we found that the tumor volume and ...

We will review the significance of survivin (BIRC5), XIAP, MCL-1, HIF1α, HIF2α, NRF2, MDM2, MDM4, TP5/p53, KRAS and AKT in treatment resistance as the potential therapeutic biomarkers and/or targets ...

MDM2 is an oncogene present in numerous cancers. The milademetan inhibitor has proven effective in a phase 1 trial on a MDM2-amplified subtype of LPS and other solid tumor types. The agent received an ...

Akt-dependent phosphorylation of MDM2 facilitates MDM2 interaction with TP53, leading to TP53 ubiquitination and degradation. The resulting decrease in TP53 restrains apoptosis and can favor ...

However, Mdm2 itself is tightly regulated by the upstream molecules to maintain p53 at an appropriate level. 30 The regulation of Mdm2 activity is mainly posttranslational modification, including self ...

Therefore, MDM2 promotes E2-dependent AKT activation in p53-depleted breast cancer cells and is also involved in ERα turnover, as previously suggested. 34 Importantly, MDM2 depletion in p53 ...

The current paradigm states that the Akt signaling pathway phosphorylates the human oncoprotein mouse double minute 2 (MDM2), leading to its nuclear translocation and degradation of the tumor ...

A phase I dose escalation study of oral MK-2206 (allosteric Akt inhibitor) with oral selumetinib (AZD6244; ARRY-142866) (MEK 1/2 inhibitor) in patients with advanced or metastatic solid tumors. This ...

Akt and Mdm2 promote AR ubiquitylation dependent on AR phosphorylation. COS‐1 cells were transfected with AR in combination with vector, cAkt or Mdm2 in the presence or absence of HA‐Ub in 10% CDS ...