6, 91054 Erlangen, Germany; epoeschlmolmed.uni-erlangen.de Background: Expression of aggrecan is reduced during aging and osteoarthritic cartilage degeneration. CpG methylation may have a role in the ...

The company's flagship product was a diagnostic test (the Fibronectin-Aggrecan Complex Test, FACT) which helps identify the source of joint pain and assists physicians in determining the most ...

Here we propose to use our recently developed biomimetic proteoglycan, aggrecan, as a novel treatment for urinary incontinence. Biomimetic aggrecan mimics the structure and osmotic properties of ...

Disc degeneration is accompanied by a decrease in aggrecan content in the nucleus pulposus. A possible approach to mechanically stabilizing the disc early in the degenerative cascade is by increasing ...

Aggrecan, a major component of proteoglycan (PG) having chondroitin sulfate (CS) in cartilaginous tissues, has become increasingly popular as an ingredient in health food. In fact, proteoglycans ...

Emerging evidence indicates the importance of PNNs in synaptic transmission at the calyx of Held. Previously, a unique differential expression of aggrecan and brevican has been reported at this ...

Injections of proteoglycan aggrecan (PGA) have been reported to induce axial spondyloarthritis (ax-SpA) in BALB/c mice. It is considered to be a model for radiographic ax-SpA. However, evaluation of ...

Confocal microscope image of cartilage cells growing within 3D printed scaffolds - stained for Aggrecan (green) and nuclei (blue). Scale bar 200 μm The new hybrid material was first printed into ...

As shown in Figure 3, Feprazone dose responsively ameliorated the reduction of Aggrecan caused by TNF-α, indicating a protective effect of Feprazone against ECM degradation induced by TNF-α. We ...

One example of this garbage is aggrecan, a protein found in the space between cells, where it inhibits neuronal growth. When aggregan it isn't maintained and cleared regularly, its levels build up and ...