In this study, we focused on understanding how interactions between CaMKIIα and the actin-crosslinking protein α-actinin-2 underlie long-lasting changes in dendritic spine architecture. We found that ...

Decision letter after peer review: Thank you for submitting your article "Molecular basis of interactions between CaMKII and α-actinin-2 that underlie dendritic spine enlargement" for consideration by ...

ACTN2 (alpha-actinin 2) anchors actin within cardiac sarcomeres. The mechanisms linking ACTN2 mutations to myocardial disease phenotypes are unknown. Here, we characterize patients with novel ACTN2 ...

We investigated the role of actin crosslinkers filamin and α-actinin by analyzing initial shear flow-stimulated responses in cells with or without these proteins. Both filamin and α-actinin showed ...

Alpha-actinin can cross-link actin filaments and anchor them to the Z-disk in sarcomeres. Sarcomeres are a structural unit of myofibril in striated muscle. The FATZ (filamin, α-actinin- and ...

ABSTRACT: The purpose of this study was to determine whether genotypes in the α-actinin-3 gene are associated with preferences in the type of exercise (sprint vs. endurance) in male college students.

One in five people lack the muscle fibre protein α-actinin-3. This mutation reveals a little bit about our evolutionary history and explains why some modern athletes succeed in the cold ...

Around one in five people lack a muscle protein called alpha-actinin-3 due to a single genetic change in the ACTN3 gene. The absence of alpha-actinin-3 became more common as some modern humans ...

Around one in five people lack a muscle protein called alpha-actinin-3 due to a single genetic change in the ACTN3 gene. The absence of alpha-actinin-3 became more common as some modern humans ...

Recent genomic studies have suggested about 20 percent of people have a novel mutation in the ACTN3 gene, which expresses a skeletal muscle protein called alpha-actinin-3. This protein is found in ...