Our results show that Tenm3 negatively regulates association between VIP and arginine vasopressin (AVP) neurons within the SCN and is essential for M1 ipRGC axon innervation to the SCN. Specifically, ...

Several neuropeptides such as arginine vasopressin (AVP) and vasoactive intestinal polypeptide (VIP) are expressed in the SCN, where these neuropeptides function as synchronizers and are important for ...

When they repeated the same experiment on AVP neurons, however -- removing key clock genes -- not only did AVP neurons themselves show disrupted rhythms, but the entire SCN stopped synchronously ...

To test the utility of the approach, Takahashi and his colleagues studied two types of cells that make up the brain's SCN—arginine vasopressin (AVP) and vasoactive intestinal polypeptide (VIP ...

On the other hand, the ‘Shell’ in mainly comprised of arginine vasopressin (AVP) expressing cells. The shell receives inputs mainly from the cortex, basal forebrain, and hypothalamus. The SCN ...

1999). A recent study of mouse SCN connectome reported that, although the direct connection from AVP neurons to VIP neurons is extremely sparse, AVP neurons make plenty of contacts onto other types of ...

Here, we utilize in vivo miniaturized microscopy to measure fluorescent GCaMP-reported calcium dynamics in arginine vasopressin (AVP)-expressing neurons in the intact SCN of awake, behaving mice. We ...

ipRGCs form synaptic contacts with major peptidergic cells of the SCN, including VIP, GRP, and arginine vasopressin (AVP) neurons, with each ipRGC innervating specific subdomains of the SCN.