The Discovery of Sotorasib (AMG 510): First-in-Class Investigational Covalent Inhibitor of KRAS G12C
KRAS is one of the most frequently mutated oncogenes in human cancer. Despite more than three decades of research, indirect approaches targeting KRAS-mutant cancers have largely failed to show ...
The FDA's conditional approval for Lumakras (sotorasib; formerly AMG-510) as a second-line treatment for KRAS G12c-mutated non-small cell lung cancer (NSCLC) has come more than two months ahead of ...
A 375-hp, turbocharged inline-six powers the GLE450, while a 510-hp, twin-turbo V-8 is used ... For high-performance buyers, Mercedes offers two AMG-tuned models: the 429-hp AMG GLE53 and 603 ...
With peak power of up to 375 kW (510 hp) and maximum torque of up to 650 Nm the new AMG V8 delivers motorsport-inspired performance. The new sports car engine follows in an impressive V8 tradition ...
The all-new S-Class is longer and is immediately available with a 510-horsepower V-12 engine as well as a high-performance S65 AMG model. The two-door version of the S-Class, the Mercedes-Benz ...
A 375-hp, turbocharged inline-six powers the GLE450, while a 510-hp, twin-turbo V-8 is used ... For high-performance buyers, Mercedes offers two AMG-tuned models: the 429-hp AMG GLE53 and 603 ...
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