The asset is not included in the pharma’s online pipeline. In 2020, Novartis picked up an anti-ADAMTS5 nanobody from Merck KGaA for 50 million euros upfront. At the time, the asset known as ...

A new study has identified the protein ADAMTS5 as playing a crucial role in the spread of ovarian cancer cells, offering a potential new target for future treatments. ADAMTS5 functions like a pair ...

A new study has identified the protein ADAMTS5 as playing a crucial role in the spread of ovarian cancer cells, offering a potential new target for future treatments. Discovery suggests that drugs ...

Correspondingly, human cartilage was digested with ADAMTS5 for different time intervals (16 hour, 24 hour and 88 hour) at 37°C. The digested cartilage was removed by centrifugation and the supernatant ...

Cellus Inc. has disclosed compounds acting as disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4; aggrecanase-1) and 5 (ADAMTS5; aggrecanase-2) inhibitors reported to be useful ...

Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China ...

Her paternal grandfather and a paternal aunt, both deceased, had dementia. Genetic analysis of the proband revealed a ~4.2Mb duplication with 9 genes spanning LINC00158 to ADAMTS5, including APP. Her ...

Based on the protein–protein interaction (PPI) networks, the hub genes of the upregulated genes (CTGF, IGF1, BMP2, MMP13, TGFB3, MMP3, and SERPINE1) and the hub genes of the downregulated genes (PPARG ...

ADAMTS5 cleaves CSPGs such as versican. "Our results in patients and animal models show that ADAMTS proteases are important for the degradation of versican in the heart and the accumulation of ...

Remodeling of the extracellular matrix (ECM) is a hallmark of heart failure (HF). Our previous analysis of the secretome of murine cardiac fibroblasts returned ADAMTS5 (a disintegrin and ...

ADAMTS5 is involved in the pathogenesis of OA. As the major aggrecanase-degrading articular cartilage matrix, ADAMTS5, has been regarded as a potential target for OA treatment. We here provide an ...