Professor I P Hall, Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University Hospital Nottingham, Nottingham NG7 2UH, UK; ...

Puzzle Piece Two: What is the Natural History of Type 1 Diabetes? The next corner piece of the puzzle that has not been gathered to impart our ability to prevent or reverse type 1 diabetes is that ...

First explained in 1978, antisense oligonucleotides are short, single-stranded synthetic fragments of DNA or RNA that bind specifically to the target RNA sequence inside cells and modulate protein ...

Objective The pathogenesis of keloid is largely unknown. Because keloid and atopic dermatitis have overlapping pathophysiological mechanisms, we aimed to evaluate keloid risk in patients with atopic ...

Human aortic smooth muscle cells (HASMCs) were transfected with lentiviral vectors carrying short hairpin RNA (shRNA) targeting ADAM33 or negative control vectors. The migration capacity of HASMCs was ...

Scientists at the Institute of Cancer Research (ICR) in London have discovered that melanoma cells spread by harnessing a gene normally involved in the development of the nervous system. The gene, ...

In addition to these findings, polymorphisms in genes (IL-10, IL-13, TLR4, VDR, CCR5, and ADAM33) have been associated with both increased incidence of bronchiolitis and subsequent asthma. For example ...

Department of Physiology, Cardiovascular Research Center, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada (T.K., Z.K.). Cardiovascular Research Center and Department of ...

Asthma is a chronic condition characterized by lung airway inflammation that is caused by both genetic and environmental factors. Image Credit: Lightspring ...