The EMBO Journal27d
A novel biosensor for the spatiotemporal analysis of STING activation during innate immune responses to dsDNA
To determine the response of the biosensor to intrinsic sources of dsDNA, we performed apoptosis, TREX1 depletion, DNA replication stress and chromosome missegregation experiments. Furthermore, we ...
ahajournals.org28d
Fast Degradation of MecciRNAs by SUPV3L1/ELAC2 Provides a Novel Opportunity to Tackle Heart Failure With Exogenous MecciRNA
Circular RNAs derived from both nuclear and mitochondrial genomes are identified in animal cells. Mitochondria-encoded circular RNAs (mecciRNAs) are attracting more attention, and several members of ...
Frontiers1y
5,6-dimethylxanthenone-4-acetic acid (DMXAA), a partial STING agonist, competes for human STING activation
Moreover, mutations in the DNase enzyme three prime exonuclease 1 (TREX1) were associated with the development of autoinflammatory conditions such as Aicardi–Goutieres syndrome (AGS) and SLE, ...
eLife12y
DNA-PK is a DNA sensor for IRF-3-dependent innate immunity
Innate immunity is the first immunological defence against pathogens. During virus infection detection of nucleic acids is crucial for the inflammatory response. Here we identify DNA-dependent protein ...