eIF1A plays an important role in start codon recognition; however, its molecular contacts with eIF5 are unknown. Using nuclear magnetic resonance, we unveil eIF1A’s binding surface on the ...

eIF5 stimulates the GTPase activity of eIF2 bound to Met‐tRNAiMet, and its C‐terminal domain (eIF5‐CTD) bridges interaction between eIF2 and eIF3/eIF1 in a multifactor complex containing Met‐tRNAiM ...

Fragile X chromosome-associated syndromes are rare genetic diseases caused by dynamic mutations of the fragile X messenger ribonucleoprotein 1 (FMR1) gene located on the X chromosome. The gene ...

In this valuable study, Tutak and colleagues set out to identify factors that mediate Repeat Associated Non-AUG (RAN) translation of CGG repeats in the FMR1 mRNA which are implicated in toxic protein ...

This contribution is part of the special series of Inaugural Articles by members of the National Academy of Sciences elected in 2015. Contributed by Alan G. Hinnebusch, August 2, 2016 (sent for review ...