eIF4E-dependent mRNA export has been shown to be mediated by a structurally conserved 4E-sensitivity element present in the 3′UTR of transcripts (Culjkovic et al., 2005, 2006).As such an element ...

The eukaryotic translation initiation factor 4E (eIF4E) plays an important role in the control of cell growth. eIF4E binds to the mRNA 5′ cap structure m 7 GpppN (where N is any nucleotide), and ...

School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, P. R. China Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems, Guangdong ...

The network for cardiac fuel metabolism contains intricate sets of interacting pathways that result in both ATP-producing and non–ATP-producing end points for each class of energy substrates. The most ...

The authors present an important set of data implicating ETFDH as an epigenetically suppressed gene in cancer with tumor suppressive functions. The evidence is solid, with the authors demonstrating ...

This work was supported by NIH R01 GM039478 awarded to C.B.P., and Anton computer time was provided by the Pittsburgh Supercomputing Center (PSC) through NIH R01GM116961. The Anton machine at PSC was ...

In recent years, protein arginine methyltransferases (PRMTs) have emerged as new members of a gene expression regulator family in eukaryotes, and are associated with cancer pathogenesis and ...

This contribution is part of the special series of Inaugural Articles by members of the National Academy of Sciences elected in 2015. Contributed by Alan G. Hinnebusch, August 2, 2016 (sent for review ...

The David Z. Rosensweig Genomics Research Center is applying genomic approaches to understand the causes and mechanisms of musculoskeletal and inflammatory conditions, including rheumatoid arthritis, ...