Each cell of the human body contains two meters of DNA. The whole secret lies in the intricate three-dimensional arrangement that allows DNA strands to be efficiently organized and compacted within ...

In a study published in Nature, researchers report the successful in vitro reconstitution of meiotic DNA double-strand breaks ...

This important manuscript proposes a new strategy for the identification of new mechanisms of drug resistance based on SAturated Transposon Analysis in Yeast (SATAY), a powerful transposon sequencing ...

Here, the authors show that intercellular bridges that connect germ cells in a syncytium are critical for ensuring proper meiotic progression and fertility in male mice. Single-cell replication ...

After more than a decade of work, researchers have reached a major milestone in their efforts to re-engineer life in the lab, putting together the final chromosome in a synthetic yeast (Saccharomyces ...

We illustrate through simple examples how this approach can be used not only in transgenerational contexts (meiotic experiments) but also in intragenerational contexts (mitotic experiments), and ...

Département de Biochimie et de Génomique Fonctionnelle, Faculté de médecine et des Sciences de la santé, Université de Sherbrooke, Sherbrooke, QC, Canada Cells were subjected to microscopic analysis ...