Researchers found that the Wnt5a protein, secreted by inflammatory fibroblasts within cancerous tumors, inhibits angiogenesis and consequently promotes hypoxia within tumors. Hypoxic conditions help ...

Mayo Clinic's Molecular Neurotherapeutics Lab demonstrated that maternal immune insults perturb microglial phenotypes and ...

The altered cells release factors that help tumors grow, such as epiregulin. In addition, they release Wnt5a protein, which helps maintain a low-oxygen state by inhibiting new blood-vessel ...

May 21, 2025 — Researchers found that the Wnt5a protein, secreted by inflammatory fibroblasts within cancerous tumors, inhibits angiogenesis and consequently promotes hypoxia within tumors.

A subset of SFRP2+ fibroblasts specifically expressed Wnt5a and was implicated in antigen processing and presentation pathway in OLP. Furthermore, SFRP2+Wnt5a+ fibroblasts amplified and maintained the ...

We compared the tumour cell mRNA with a single reference probe, providing normalized measures of the expression of each gene in each sample relative to the standard. Analysis of the normalized ...

The study presents extensive gene expression profiling and bioinformatic analyses, offering insights into the roles of fibroblasts in cardiac development. The large volume of scRNA-seq data is both ...

This important study demonstrates the therapeutic potential of recombinant human PDGF-AB/BB proteins in reducing the senescent signatures of primary human intervertebral disc cells. The study ...

We first assayed whether Wnt stimulation is capable of activating JNK in cultured cells. We tested two Xenopus Wnt ligands, Xenopus Wnt5a and Xenopus Wnt8, for their activity to activate members of ...