Additionally, CRISPR/Cas gene editing was applied to healthy stem cells to study the roles of GFAP and vimentin. The absence of both proteins impaired organoid development, particularly in the cortex.

This important study sheds light on the role of sphingolipids on the maturation of Parkinson's disease-associated Synphilin-1 inclusion bodies (SY1 IBs) on the mitochondrial surface in a yeast model ...

Due to proteostasis stress induced by aging or disease, misfolded proteins can form toxic intermediate species of aggregates and eventually mature into less toxic inclusion bodies (IBs). Here, using a ...

Department of Chemistry, Indian Institute of Technology Palakkad, Palakkad, Kerala 678623, India Physical and Chemical Biology Laboratory, Indian Institute of Technology Palakkad, Palakkad, Kerala ...

The possible involvement of other cellular components in viral entry mechanisms remains unknown. Vimentin is expressed in human endothelial cells, binds to SARS-CoV-2-spike, and expedites SARS-CoV-2 ...

Vimentin protein has been identified as a potential receptor for JEV, engaging in interactions with the viral membrane protein. The Fc fragment, an integral constituent of immunoglobulins, plays a ...

Here, we present a perspective on the putative role of plant-produced resveratrol oligomers as anti-virulence and plant-immune priming agents for efficient disease management. Resveratrol oligomers ...