In lab studies, the orally active drug has been shown to degrade the VAV1 protein expressed in T- and B- cells. VAV1 is thought to be a signalling protein involved in the production of pro ...

Koncz, G., Kerekes, K., Chakrabandhu, K. & Hueber, A. O. Regulating Vav1 phosphorylation by the SHP-1 tyrosine phosphatase is a fine-tuning mechanism for the negative regulation of DISC formation ...

Embryo development requires precise coordination of molecular and cellular processes. Cell proliferation, migration, fate and 3D spatial organization, all essential during development, are controlled ...