US pharma giant Merck & Co today announced that the European Commission (EC) has conditionally approved two indications for Welireg (belzutifan), its oral hypoxia-inducible factor-2 alpha (HIF-2α) ...

HIF-2α inhibition by small hairpin RNA or selective small molecule antagonist blocked the increases in pro-inflammatory molecule expression and T cell migration induced by acidic bile salts.

zju.edu.cn Objective We aimed to elucidate the mutual regulation mechanism of ubiquitin-specific protease 22 (USP22) and hypoxia inducible factor-1α (HIF1α), and ... Results USP22 promotes ...

Ordinarily, HIF-mediated induction of VEGF would provide a rapid and direct mechanism to protect motor neurons during such periods of mild hypoxia. But deletion of the HRE element in the VEGF gene ...

Edited by Anne C. Hart, Brown University, Providence, RI; received August 29, 2024; accepted December 19, 2024 by Editorial Board Member Yishi Jin Taken together, these results identify VHL-1 as a ...

Edited by Anne C. Hart, Brown University, Providence, RI; received August 29, 2024; accepted December 19, 2024 by Editorial Board Member Yishi Jin ...

Hypoxia-induced iron overload in the placenta leads to a diminished GPx4 (glutathione peroxidase 4) antioxidant defense and heightened lipid peroxidation thereby triggering ferroptosis in pregnancies ...

§ p = 0.0001 between temsirolimus and IFN-α. ¶ p = 0.0001. # p = 0.0001. ** p = 0.001. NR: Not reported; ORR: Overall response rate; OS: Overall survival; PFS ...

Neonatal cerebral hypoxia-ischemia (HI) is the leading cause of death and disability in newborns with the only current treatment being hypothermia. An increased understanding of the pathways that ...

Moreover, HIF-1α is involved in many oxLDL-induced effects in macrophages including ... genes implicated in inflammation (interleukin 1-β), angiogenesis (vascular endothelial growth factor (VEGF) and ...

Figure 2 The underlying mechanisms of hypoxia-induced drug-resistant NSCLC ... Epidermal growth factor receptor; VEGF, Vascular endothelial growth factor; HIF-1α, Hypoxia inducible factor-1alpha; ...