The Pharma Letter4d
Welireg bags two indication nods from EC
US pharma giant Merck & Co today announced that the European Commission (EC) has conditionally approved two indications for Welireg (belzutifan), its oral hypoxia-inducible factor-2 alpha (HIF-2α) ...
The EMBO Journal5d
Repression of apelin Furin cleavage sites provides antimetastatic strategy in colorectal cancer
Furin is identified as the key enzyme responsible for cleaving the apelin precursor. Inhibiting this cleavage could serve as ...
gut.bmj15d
Hypoxia-inducible factor-2α plays a role in mediating oesophagitis in GORD
HIF-2α inhibition by small hairpin RNA or selective small molecule antagonist blocked the increases in pro-inflammatory molecule expression and T cell migration induced by acidic bile salts.
PNAS23d
Suppressing APOE4-induced neural pathologies by targeting the VHL–HIF axis
Edited by Anne C. Hart, Brown University, Providence, RI; received August 29, 2024; accepted December 19, 2024 by Editorial Board Member Yishi Jin Taken together, these results identify VHL-1 as a ...
PNAS25d
Suppressing APOE4-induced neural pathologies by targeting the VHL–HIF axis
Edited by Anne C. Hart, Brown University, Providence, RI; received August 29, 2024; accepted December 19, 2024 by Editorial Board Member Yishi Jin ...