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pharmaphorum1d
Merida raises $121m for Graves drug, and other financings
Attovia Therapeutics has also completed a third-round financing, gathering $90 million to help fund early-to-mid-stage clinical trials of two biology drugs, IL31-targeting ATTO-1310 in chronic ...
C&EN6d
Ethyl Acetate Fraction of Zanthoxylum bungeanum Ameliorates Cognitive Deficit by Facilitating the PHGDH-Dependent Astrocyte-Neuron Serine Shuttle in Aging Mice - ACS Publications
Moreover, EA markedly enhanced glycolytic flux in the brain of aging mice and U87 cells, evidenced by the elevated enzymatic activities of hexokinase (HK), 6-phosphofructokinase (PFK), and pyruvate ...
C&EN6d
Development of Dual PLD1/2 and PLD2 Selective Inhibitors from a Common 1,3,8-Triazaspiro [4.5]decane Core: Discovery of ML298 and ML299 That Decrease Invasive Migration in U87 ...
An iterative parallel synthesis effort identified a PLD2 selective inhibitor, ML298 (PLD1 IC50 > 20 000 nM, PLD2 IC50 = 355 nM) and a dual PLD1/2 inhibitor, ML299 (PLD1 IC50 = 6 nM, PLD2 IC50 = 20 nM) ...