A new study highlights how both neuronal and peripheral tissues become disrupted in Alzheimer’s disease. A team of researchers from Baylor College of Medicine (TX, USA), the Jan and Dan Duncan ...

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The pseudouridine at position 43 in vertebrate U2 snRNA is one of the most conserved post -transcriptional modifications of spliceosomal snRNAs; the equivalent position is pseudouridylated in U2 ...

Trophoblast organoids recapitulate syncytiotrophoblast nuclear heterogeneity and reveal environment-dependent gene regulation critical for placental hormone production and differentiation.

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The intricate higher-order structure of chromatin within the cell nucleus has been extensively elucidated through the efforts of the four-dimensional nucleome (4DN) project (The 4D Nucleome Network et ...

The immunostaining results presented are clear and robust. The authors performed well-controlled analyses against relevant mouse models. snRNA-seq corroborates immune cell leakage in the retina and ...

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This study has used snRNA-seq, spatial transcriptomics and advanced bioinformatic approaches to generate comprehensive transcriptomic and spatial profiles of the human IFP. By applying these high ...

New research using fruit flies reveals that Alzheimer’s disease impacts not just the brain, but the entire body. Alzheimer’s disease is usually thought of as a brain disorder, but new research ...