Scientists peel away the mystery of JAK enzymes, which play roles in everything from eczema to ulcerative colitis
Pharmaceutical ads are difficult to avoid in American television programming and a growing number of them promote a class of ...
Nature8d
The anaplastic lymphoma kinase in the pathogenesis of cancer
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase first identified ... (ALCL), driving transformation through many molecular mechanisms. In this Review, we will analyse how ...
Medscape8d
Targeted Drugs in Oncology: New Names, New Mechanisms, New Paradigm
The molecular mechanisms of action ... extracellular portion of RTKs and small-molecule inhibitors of their tyrosine kinase activity are strategies in more advanced phases of clinical development.
Ocean Biomedical advances in cancer immunotherapy
PROVIDENCE, RI - Ocean Biomedical (NASDAQ: OCEA) has announced research findings that show its immunotherapy candidates can work synergistically with tyrosine kinase inhibitors (TKIs), potentially ...
ophthalmologytimes14d
Tyrosine kinase inhibitor: An alternative treatment for non–small-cell lung cancer metastasis to the choroid
Investigators conducted a retrospective review that spanned 10 years with the goals of describing the clinical ...
Nature23y
New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades
Together, these novel mechanisms of GPCR-mediated MAPK regulation ... including phospholipase Cγ and the non-receptor tyrosine kinase c-Src. EGFR activation also leads to tyrosine phosphorylation ...
Too Old to Operate8d
Bruton’s tyrosine kinase inhibition re-sensitizes multidrug-resistant DLBCL tumors driven by BCL10 gain-of-function mutants to venetoclax.
Disparate pathogenic mechanisms complicate precision-medicine efforts to treat diffuse large B-cell lymphoma (DLBCL), the most common lymphoma diagnosis. Though potentially curable with frontline ...
Ocean Biomedical Announces Breakthrough Findings in EGFR-Mutant Lung Cancer and Plans for FDA Alignment on Next-Stage Development
Company Poised to Enter Booming Bispecific Antibody Market Amid Growing Pharma Interest Providence, RI, Feb. 10, 2025 (GLOBE NEWSWIRE) -- Ocean Biomedical (NASDAQ: OCEA) today announced newly ...
William & Mary6y
Shantá Hinton
Cellular and molecular biology, protein tyrosine phosphorylation ... My lab focuses on various functional characteristics of the pseudophosphatase map kinase serine/threonine binding protein (MK-STYX) ...