Double-strand DNA break was generated using guide RNA targeting the region near the stop codon of the Tnfsf11 gene. Homology-directed repair donor was synthesized as a 1.1-kb single-stranded DNA ...

Characterized by hydroxyapatite deposition in necrotic myocytes, myocardial calcification is common in specific forms of cardiomyopathy and in myocardial infarction. It has been estimated that ≈8% of ...