This manuscript focuses on developing a structural model of how the multidomain ECM protein SVEP1 enables Angiopoietin (ANG) binding to the orphan receptor TIE1, resulting in downstream receptor ...

The Tie family of receptors, Tie1 and Tie2, are highly homologous receptor tyrosine kinases (RTKs). In contrast to Tie2 signal transduction, Tie1 signaling is still poorly understood. To investigate ...

Recent findings suggest that combined administration of the angiogenic factors Ang1 and VEGF may improve current therapeutic approaches for inducing formation of new blood vessels. However, many ...

To further explore mechanisms of Tie2 regulation, we have studied its expression in bovine aortic and human umbilical vein and small-vessel ECs, including primary cultures of cardiac microvascular ECs ...

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Research is supported by NIH Grants R01CA247441, R21EB031982, U01CA261842, and R01CA284603. The funders played no role in the preparation of the manuscript. Note: The article usage is presented with a ...

We invite you to browse our collection of recent and insightful EMBO Molecular Medicine articles centered on cancer metastasis. The selected research covers a wide range of topics from the role of the ...

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