T helper 17 (Th17) cells generate the pro-inflammatory cytokine interleukin-17 (IL17/IL17A). IL17 has been a target for a variety of therapeutic monoclonal antibodies and inhibitors to treat ...

One of the most recent and perhaps most promising developments in psoriasis research is the role of the Th17 CD4 + T cell and one of its cytokines, IL-17, in disease development, progression and ...

Interleukin-22 (IL-22) is a cytokine related to IL-10 for its structure and is secreted by T helper type 17 (TH17) cells and innate immune cells. Given the paradoxical role of IL-22 in ...

Increased numbers of Th17 cells are found in inflamed tissue ... rather than blockade of either cytokine alone.

Th17 lymphocytes produce the pro-inflammatory cytokine IL-17 which provides protection against mainly extra-cellular pathogen infections. However IL-17 release has been hardly studied in neonates.

Guselkumab targets the p19 alpha subunit of IL-23. While IL-23 promotes normal inflammatory and immune responses, the p19 and ...