This study provides evidence that single-cell multi-omics profiling can reveal key regulators of HIV-1 persistence and early immune dysregulation, particularly implicating KLF2 and Th17 cells as major ...

Aclaris Therapeutics (ACRS) announced the availability of a new publication describing properties of Aclaris Therapeutics’ ATI-2138, a novel ...

Role of inflammatory cytokines in establishing granuloma formation ... IL12 or Th2 cells in presence of IL4 or Th17 cells in presence of TGFβ, IL17, IL23. These cells also reach the site of infection ...

These cytokines in turn activate the IL-23 and/or IL-22 pathway to induce Th17 and/or Th22 cell differentiation, resulting in the production of numerous psoriatic cytokines, such as TNF-α, IFN-γ, ...

Studies in animal models suggested that Th17 cells are the candidates ... Our comprehensive analysis of cytokine production demonstrates the landscape of helper T cell populations in RA joints: ...

One of the most recent and perhaps most promising developments in psoriasis research is the role of the Th17 CD4 + T cell and one of its cytokines, IL-17, in disease development, progression and ...