Among these, the Tbx1 gene has emerged as a critical regulator of stem cell function in the brain, as highlighted in prior studies by Hiroi and colleagues. Variants in Tbx1 are strongly associated ...

Apr. 17, 2024 — Researchers have identified a variant in the gene TBX1 as key in the development of the unique morphology at the base of the skull. TBX1 is present at higher levels in humans ...

RBPs (RNA-binding proteins) perform indispensable functions in the post-transcriptional regulation of gene expression. Numerous RBPs have been implicated in cardiac development or physiology based on ...

Background: Aberrant right subclavian artery (ARSA) is becoming increasingly common in fetuses. However, there are relatively fewer studies regarding the genetic etiology of ARSA. We performed a ...

This review provides an updated summary of the state of our knowledge of the genetic contributions to the pathogenesis of congenital heart disease. Since 2007, when the initial American Heart ...

During the past decade, considerable progress has been made in our understanding of the fundamental molecular mechanisms underlying the role of innate immunity and inflammatory responses in OM (Kurabi ...

Background: Double outlet right ventricle (DORV), a clinically significant congenital heart defect, occurs in 1–3% of individuals with congenital heart defects. In contrast to other major congenital ...

Edited by Eric N. Olson, University of Texas Southwestern Medical Center, Dallas, TX, and approved January 13, 2017 (received for review March 29, 2016) ...