A 3D engineered kidney glomerulus model replicates structural and mechanical features of the glomerular filtration barrier, ...

as well as TRPC6 inhibitor BI 764198 in phase 2 for rare kidney disease focal segmental glomerulosclerosis (FSGS). In oncology, she highlighted MDM2-p53 antagonist brigimadlin, which has advanced ...

2017). TRPC3 shares a high degree of homology with TRPC6, and both are activated by diacylglycerol. TRPC proteins are broadly expressed in vascular endothelial cells and smooth muscle cells. TRPC3 and ...

Exercise intolerance is a hallmark of heart failure with preserved ejection fraction (HFpEF) and is characterized by skeletal muscle (SkM) dysfunction with impaired oxidative capacity. To maintain ...

Advancing age promotes cardiovascular disease (CVD), the leading cause of death in the United States and many developed nations. Two major age-related arterial phenotypes, large elastic artery ...

Cardiac arrhythmias are characterized by disturbances in the heart’s electrical activity and contribute greatly to cardiovascular morbidity and mortality (1). Although antiarrhythmic drugs (AADs) are ...

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