Researchers report that rentosertib, an AI-discovered TNIK inhibitor, showed promising safety and potential to improve lung ...

Insilico plans late-stage trials for rentosertib following positive mid-stage safety and efficacy data for idiopathic ...

For instance, Insilico’s leading drug candidate INS018_055 targets Traf2- and Nck-interacting kinase (TNIK), which is not only a novel target against IPF identified by PandaOmics, but also has ...

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Switzerland Centre of Regenerative Medicine, Medical University of Bialystok, Bialystok, Poland 1. Jin L, Ding M, Cui S, et ...

Since ponatinib inhibits Traf2-and Nck-interacting kinase (TNIK), I hypothesized that TNIK modulates ERK5 transcriptional activity. Using a mammalian one-hybrid assay and quantitative RT-PCR (qRT-PCR) ...

Activated RIPK1 is rapidly ubiquitinated and degraded by the TRAF2-cIAP1-cIAP2 complex, thereby maintaining the signal homeostasis of the TNF-TNFR2 axis. Activated RIPK1 promotes the activation of IKK ...

A novel application of deep learning (DL)-based MRI with liquid biomarkers for immune effector cell-associated neurotoxicity syndrome (ICANS) after chimeric antigen receptor (CAR) T-cell therapy. This ...

Transdifferentiation of adventitial fibroblasts (AFs) into myofibroblasts plays a critical role during the vascular remodeling that occurs during atherosclerosis ...

Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, People’s Republic of China Zhejiang Key Laboratory of Precise Diagnosis ...