Researchers report that rentosertib, an AI-discovered TNIK inhibitor, showed promising safety and potential to improve lung ...

Insilico plans late-stage trials for rentosertib following positive mid-stage safety and efficacy data for idiopathic ...

For instance, Insilico’s leading drug candidate INS018_055 targets Traf2- and Nck-interacting kinase (TNIK), which is not only a novel target against IPF identified by PandaOmics, but also has ...

Activated RIPK1 is rapidly ubiquitinated and degraded by the TRAF2-cIAP1-cIAP2 complex, thereby maintaining the signal homeostasis of the TNF-TNFR2 axis. Activated RIPK1 promotes the activation of IKK ...

Animal cells respond to differentiation signals which turn on or off the appropriate genes, resulting in the conversion of proliferating, undifferentiated cells into nonproliferating, highly ...

In a small fraction of mammalian genes, one of the two alleles is partially or completely switched off. The decision as to which one is silenced depends on which allele was inherited from the ...

Transdifferentiation of adventitial fibroblasts (AFs) into myofibroblasts plays a critical role during the vascular remodeling that occurs during atherosclerosis ...