Knockdown of TRIM27 expression leads to increased NF-κB and IRF3–IRF7 activation, which indicates that this TRIM protein is a negative regulator of TLR and other signalling pathways.

Get Instant Summarized Text (Gist) Time-Lagged Recurrence (TLR) is a data-driven method for quantifying the predictability of complex dynamical systems using only observational data.

In addition to two full conference days to STING/TLR-targeting, there will be a pre-focus day specifically on innate immune checkpoints and the activation of specific cell types including natural ...

Results: Our findings revealed that knocking out ADAR1 induces dsRNA accumulation, activating the TBK1-IRF3 pathway and stimulating ISG expression, which in turn activates anti-tumour immunity and ...

Pirelli has launched the Cinturato Evo TLR, a successor to the Cinturato Velo. While retaining the Cinturato Velo’s reliability and puncture protection, the Cinturato Evo TLR features SmartEVO AS, ...

Subjects and methods The study subjects were female Balb/c pristane-induced lupus mice model, 8–12 weeks of age, n=30, divided into two groups, nephritis (LN group) and non-nephritis (SLE group). The ...

We revealed a mechanism in which a viral protein promotes the direct RIPK3 activation leading to inflammatory necroptosis and pathogenesis. The nonstructural protein NSs of a pathogenic hemorrhagic ...

ZSA-215 enhanced STING signaling through promoting the phosphorylation of STING and interferon regulatory factor 3 (IRF3) and secretion of IFN-β. Notably, monotherapy of oral ZSA-215 achieved complete ...