Among the three kinases (PLK1, STK33 and TBK1) that were the focus of follow-up experiments, only TBK1 had been previously linked to Ras (through a pathway involving the exocyst complex ...

Tumor development is an evolutionary process driven by an accumulation of mutations allowing cells to acquire traits that can ultimately lead to a cancerous state. [1] As a consequence cancer is ...

This valuable study aims to advance the toolkit of small molecules used for approaches to targeted protein degradation for research and therapeutic applications. The authors provide solid data ...