In related news, other scientists recently reported that phospho-tau isoforms in the CSF mirror protofibrillar forms of tau, ...

The defective proteins are called Amyloid‑beta (Aβ) toxic oligomers. The test from AltPep is called the Soluble Oligomer Binding Assay (SOBA‑AD). The research was published Thursday in the ...

The prevailing scientific view today is that it is not the plaques but soluble Aβ aggregates, known as Aβ oligomers, that cause the early pathological changes in Alzheimer’s disease.

Important issues that will need to be addressed include the possibility that increased levels of soluble Aβ might also contribute to pathophysiology in AD. A phase II clinical trial of clioquinol ...

The severity of dementia inversely correlates with measures of synaptic density. Soluble oligomers of Aβ are the earliest effectors of synaptic compromise in Alzheimer's disease. [1] There are ...

While the soluble Aβ monomers are constitutively ... metal concentrations may prevent Aβ precipitation, covalent Aβ oligomer formation and toxic redox activity. Aβ: Amyloid-β; AICD: Amyloid ...

The monomer, oligomer and fibrillar forms of the Aβ protein are distinguished using THz near-field conductance measurements. Independently of the protein concentration, the DQ index goes from ...

Cordance’s SonoScript technology will be leveraged to assess how focused ultrasound can enhance the brain biodistribution of Abyssinia’s soluble oligomer ... and safety of Aβ immunotherapy.

The inclusion of the Arctic mutation along with the Swedish mutation in the transgene results in more prominent Aβ pathology, including elevated soluble Aβ aggregates such as Aβ protofibrils, greater ...