In a study published in Journal of Clinical Investigation, researchers used mouse models and studies of colorectal cancer tissues to show that loss of SOX9 gene promotes tumor progression and the ...

Low or absent SOX9 levels are linked to increased tumor invasiveness via epithelial-mesenchymal transition and correlate with poorer overall survival, indicating SOX9’s role as a tumor suppressor.

To better understand the role of SOX9, the team turned to mouse models. They inactivated the genes for SOX9 and APC in colon tissues. APC is a tumor suppressor gene and is inactivated in 80% of ...

In this study, mice expressing red and green fluorescent proteins in the expression domains of Scx and Sox9, respectively, were used to visualize the desired biological event of interest.

A team of researchers at Baylor College of Medicine, UMass Chan Medical School and Cincinnati Children’s Hospital Medical ...

A team of researchers at Baylor College of Medicine, UMass Chan Medical School and Cincinnati Children's Hospital Medical ...

The SRY-related transcription factor SOX9 is expressed in the mammalian pancreaticobiliary ductal system, but the perinatal lethality of Sox9 heterozygous mice makes loss-of-function analyses ...

Edited by Stefan Mundlos, Max Planck Institute for Molecular Genetics, Berlin, Germany; received December 23, 2021; accepted September 10, 2022 by Editorial Board Member Denis Duboule ...