Src homology 3 (SH3) domains are small non‐catalytic protein modules capable of mediating protein–protein interactions by binding to proline‐X‐X‐proline (P‐X‐X‐P) motifs. Here we demonstrate that the ...

Phosphorylation of the human p52Shc adaptor protein is a key determinant in modulating signaling complex assembly in response to tyrosine kinase signaling cascade activation. The underlying mechanisms ...