In-house, Sangamo is developing a zinc-finger repressor targeting the sodium voltage-gated channel alpha subunit 9 (SCN9A) gene that encodes the Nav1.7 sodium channel, which is implicated in ...

Peripheral neuropathy is a common finding in patients with complex inherited neurological diseases and may be subclinical or a major component of the phenotype. This review aims to provide a clinical ...

In parallel, epigenetic mechanisms such as DNA methylation and histone modifications alter the expression of pain-related genes (e.g., SCN9A, BDNF), establishing a long-term transcriptional ...