Moreover, there was no increased apoptotic activity in β cells of S6K1-deficient mice, as judged by propidium iodide and Hoechst staining, or by electron microscopy, ruling out higher β-cell ...

However, the downstream of mTOR signaling pathway remains elusive. This study investigates the effect of 17β-estradiol (E2) on intervertebral disc degeneration (IVDD) through the p70 S6K1 signaling ...

Background and objective Low-load exercise training with blood flow restriction (BFR) can increase muscle strength and may offer an effective clinical musculoskeletal (MSK) rehabilitation tool. The ...

Circadian disruption, occurring in shift work, sleep deprivation, or dementia, increases the risk of sarcopenia, the age-related loss of muscle mass and strength. The cell-intrinsic and extrinsic ...

The network for cardiac fuel metabolism contains intricate sets of interacting pathways that result in both ATP-producing and non–ATP-producing end points for each class of energy substrates. The most ...

Advancing age promotes cardiovascular disease (CVD), the leading cause of death in the United States and many developed nations. Two major age-related arterial phenotypes, large elastic artery ...

The authors present an important set of data implicating ETFDH as an epigenetically suppressed gene in cancer with tumor suppressive functions. The evidence is solid, with the authors demonstrating ...

Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, Georgia 30322, United States ...

kDivision of Pathology and Data Analytics, Leeds Institute of Medical Research at St James's University, University of Leeds, Leeds, UK ...

Cell-based high-content approach for SARS-CoV-2 neutralization identifies unique monoclonal antibodies and PI3K pathway inhibitors in Molecular and Cellular Pathology Carly R. Cabel Briana A. Guzman ...