BACKGROUND: Dilated cardiomyopathy (DCM) is substantially influenced by genetic factors. Sarcomere function is intricately associated with other organelles, particularly the reciprocal regulation ...

RAF1 signalling leads to the acetylation of Toll-like receptor (TLR)-activated nuclear factor-κB (NF-κB) subunit p65 and affects cytokine expression, such as inducing the upregulation of ...

Proof of this was the onerous new requirements RAF tried to impose on traffic accident victims, by the introduction in 2022 of a new “RAF1 form” without having followed the proper administrative ...

RAF1, MAP2K1 and MAPK1). Signalling upregulation also results from inefficient signalling switch-off operated by multiple feedback mechanisms (ie, defective function of CBL, NF1, LZTR1 and SPRED1).

Dual targeting of VEGF and PD-1: A phase I/II trial of ivonescimab, a novel bispecific antibody, in recurrent glioblastoma. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This ...

Anti-tumor activity of BH-30643, a novel macrocyclic kinase inhibitor, in EGFR-mutant lung cancer models. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This abstract does not ...

Apr. 7, 2025 — As many as one in 3,000 people could be carrying a faulty gene that significantly increases their risk of a punctured lung, according to new ... Apr. 2, 2025 — Lung cancer ...

Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. In the study of protein dynamics and interactions, ...

† Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China ‡ State key Laboratory of Drug Research, ...