Nucleolar size acts as a built-in mortality timer in yeast * Crossing a size threshold disrupts cell stability and ...

The Fanconi anemia (FA) pathway is a critical DNA damage response mechanism responsible for the repair of replication barriers such as interstrand crosslinks (Raschle et al, 2008), R-loops (Hodson et ...

This includes Rad52, a protein involved in DNA repair. Its unregulated entry sparks a cascade of recombination errors in the DNA, leading to genome instability and eventually, cellular collapse .

Genomic instability encompasses a range of genetic alterations from point mutations to chromosome rearrangements. From the perspective ofcis and trans-acting elements, these authors provide a ...

De Tullio L, Kaniecki K, Kwon Y, Crickard JB, Sung P, Greene EC (2017) Yeast Srs2 helicase promotes redistribution of single-stranded DNA-bound RPA and Rad52 in homologous recombination regulation.

We also queried post-translational modifications reported for Srs2 by mutating the corresponding modification sites ().First, seven Cdk1 phosphorylation consensus sites of Srs2 were mutated to produce ...

The rational design of selective kinase inhibitors remains a great challenge. Here we describe a physics-based approach to computationally modeling the kinase inhibitor selectivity profile. We ...

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