A powerful new discovery reveals that Nup98 a protein once thought to only ferry molecules through the nucleus plays a vital ...

This landmark study describes the structure of the human RAD51 filament with a recombination intermediate called the displacement loop (D-loop). Using cryogenic structural, biochemical, and ...

A unique feature of HR is that it repairs the damage to the DNA in a highly accurate way. In eukaryotic cells (those with a ...

When DNA breaks inside the cell, it can spell disaster, especially if the damage occurs in areas of the genome that are difficult to repair. Now ...

When DNA breaks inside the cell, it can spell disaster, especially if the damage occurs in areas of the genome that are ...

The research, published today as a Reviewed Preprint in eLife, is described by the editors as a landmark study with compelling evidence on how an important player in DNA repair – the RAD51 ...

When DNA breaks inside the cell, it can spell disaster, especially if the damage occurs in areas of the genome that are ...

The research group led by Professor Hitoshi Kurumizaka, Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, has revealed how the DNA repair ...

Phase IIa study of BVAC-C in HPV type 16 or 18 positive recurrent cervical carcinoma. Progression-free survival (PFS) and second PFS (PFS2) by disease stage in patients (pts) with homologous ...

In HRR, BRCA proteins help form radiation-sensitive 51 (RAD51)-single-stranded DNA (ssDNA) filaments, which are essential for invading and repairing damaged DNA using homologous sequences as ...